SHSY-5Y Tet-On Inducible Alpha-Synuclein Neuroblastoma Cell Line

Descrição detalhada : The SHSY-5Y Tet-ON inducible alpha-synuclein neuroblastoma cell line serves as a model for both dopaminergic neuronal biology and alpha-synuclein pathology. SHSY-5Y cells may be induced upon treatment with retinoic acid to differentiate into neuronal-type cells, enabling studies of neuronal function and differentiation.4 SHSY-5Y cells secrete catecholamines and thus serve as a model for dopaminergic neurons. The SHSY-5Y TetON alpha-synuclein inducible cell line harbors an alpha-synuclein construct inducible by treatment with doxycycline, thus allowing controlled overexpression of alpha-synuclein before or after neuronal differentiation.5 The construct also includes a tet repressor, which prevents leaky expression in absence of inducer. This unique cell line is an excellent model for both the basic cellular physiology of Parkinson's disease and therapeutic development.
Sinónimos : SHSY-5Y Tet-On Inducible Alpha-Synuclein Neuroblastoma Cell Line
Armazenamento : <= - 140C