Anti-KCNT1 Antibody

Descrição detalhada : Potassium channel subfamily T member 1 (UniProt: Q9Z258; also known as Sequence like a calcium-activated potassium channel subunit, Slack, KCNT1) is encoded by the Kcnt1 (also known as Slack) gene (Gene ID: 60444) in rat. KCNT1 is a multi-pass membrane protein that serves as an outwardly rectifying potassium channel subunit that may co-assemble with other Slo-type channel subunits. It represents the largest known potassium channel subunit. It is activated by high intracellular sodium or chloride levels and is activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. KCNT1 has four cytoplasmic domains, six transmembrane domains, and four extracellular domains. It is widely expressed in the nervous system and its activity contributes to the slow hyperpolarization that follows repetitive firing. KCNT1 is phosphorylated by protein kinase C and phosphorylation of the C-terminal domain is shown to increase its channel activity by 2 to 3-folds. Mutations in Kcnt1 gene have been linked to malignant migrating partial seizures of infancy (MMPSI), a rare epileptic encephalopathy of infancy. Two isoforms of KCNT1 have been described that are produced by alternative splicing. (Ref.: Barcia, G., et al. (2012). Nat. Gen. 44(11); 1255-1259).
Armazenamento : 2-8C
Embalagem : 1X25UL