BCH245 Human H3K27M Glioma Cell Line

Descrição detalhada : Glioma, a type of tumor that occurs in the brain and spinal cord and originates in the supportive glial cells surrounding nerve cells, is one of the most common types of primary brain tumors. Low-grade gliomas are the predominant glioma diagnosis among children, with very good prognosis and extremely rare malignant progression. Conversely, high-grade gliomas (HGG) are aggressive cancers and considered one of the most lethal tumors affecting the pediatric age group.1 Diffuse midline gliomas (DMG) with histone H3 lysine27-to-methionine mutations (H3K27M glioma) represent a highly aggressive subtype of glioma, which predominantly arise in children and young adults. The overall prognosis of H3K27M glioma is poor, displaying median survival rates of approximately 9 to 11 months.2BCH245 cell line is a patient-derived model of H3K27M glioma.3 BCH245 cells grow as neurospheres in suspension culture and have been characterized via expression of epidermal growth factor receptor (EGFR). BCH245 cells have demonstrated utility in unraveling the mechanisms of glioma tumorigenesis and physiology,4 representing a clinically relevant model for this especially serious type of glioma.Source BCH245 was derived from diffuse midline glioma in Pons tissue of a male pediatric patient.3References1. Sci Rep 2020, 10(1): 83682. Front Oncol 2020, 9:1436.3. Science 2018, 360(6386): 331-335.4. Nat Commun 2019, 10(1): 1262.
Armazenamento : -196C
Embalagem : 1X1EA