WAY-100635 Maleate – CAS 634908-75-1 – Calbiochem

Descrição detalhada : A selective 5-HT1A receptor antagonist (pKi = 7.9-9.2). WAY-100635 has been reported to have good inhibitory action centrally and peripherally (1mg/kg dose in rats) but has low intrinsic effects, making it a silent 5-HT1A receptor antagonist. WAY-100635 displaced specific binding of the 5-HT1A radioligand, [3H]8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin), to rat hippocampal membranes with a pIC50 of 8.87. This represented a greater than 100-fold selectivity relative to binding at other 5-HT receptor subtypes and major neurotransmitter receptor, reuptake and ion channel sites. WAY-100635 has been used in a variety of vertebrate species in vivo and in vitro.
Sinónimos : WAY-100635 Maleate - CAS 634908-75-1 - Calbiochem; 5-HT 1A Serotonis Receptor Antagonist, WAY-100635 Maleate, WAY 100635, WAY100635; 5-HT1A Serotonis Receptor Antagonist, WAY-100635 Maleate, WAY 100635, WAY100635
Fórmula molecula r: C25H34N4O2 · xC4H4O4
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X1EA