ZD 7288 – CAS 133059-99-1 – Calbiochem

Descrição detalhada : A potent blocker of hyperpolarization-activated cyclic nucleotide-gated channels (HCN channels) in heart and brain tissue. Recently shown to also block Na(+) currents in DRG neurons and in HEK293 cells transfected with Na(v)1.4 plasmids. In voltage clamp experiments, it is shown to reduce Ih in a time- and concentration-dependent manner (IC50 = 2 mM). Suggested to behave as a lipophilic quaternary cation that can pass into the cell interior to block Ih channels in their closed state., A potent blocker of hyperpolarization-activated cyclic nucleotide-gated channels (HCN channels) in heart and brain tissue. Recently shown to also block Na(+) currents in DRG neurons and in HEK293 cells transfected with Na(v)1.4 plasmids. In voltage clamp experiments, it is shown to reduce Ih in a time- and concentration-dependent manner (IC50 = 2 mM). Suggested to behave as a lipophilic quaternary cation that can pass into the cell interior to block Ih channels in their closed state.Please note that the molecular weight for this compound is batch-specific due to variable water content.
Sinónimos : ZD 7288 - CAS 133059-99-1 - Calbiochem; Zeneca, HCN Channel Blocker, ZD 7288, ZD-7288, ZD7288
Fórmula molecula r: C15H21ClN4
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X1EA