11beta-HSD1 Inhibitor, 10j – CAS 1009373-58-3 – Calbiochem

Descrição detalhada : A cell permeable, spirocyclic urea that acts as a selective inhibitor of 11beta-hydroxysteroid dehydrogenase 1 (11beta-HSD1) (IC50 of 1.6 nM and 5.3 nM) in enzyme and human adipocyte assays, respectively. Consisting of 2 enantiomers, 10j2 (R Isomer) is shown to be ˜ 2-3X more potent than 10j1 (S Isomer), in both aforementioned assays. 11beta-HSD1 activity in the presence of 10j2 (10mg/kg in animals p.o.) results in an ˜ 80% reduction in the concentration of plasma cortisol over vehicle treated controls., A cell permeable, spirocyclic urea that acts as a selective inhibitor of 11beta-hydroxysteroid dehydrogenase 1 (11beta-HSD1) (IC50 of 1.6 nM and 5.3 nM) in enzyme and human adipocyte assays, respectively. Consisting of 2 enantiomers, 10j2 (R Isomer) is shown to be ˜ 2-3X more potent than 10j1 (S Isomer), in both aforementioned assays. 11beta-HSD1 activity in the presence of 10j2 (10 mg/kg in animals p.o.) results in an ~80% reduction in the concentration of plasma cortisol over vehicle treated controls.
Sinónimos : 11beta-HSD1 Inhibitor, 10j - CAS 1009373-58-3 - Calbiochem
Fórmula molecula r: C26H33BrN2O3
Armazenamento : 2-8C; 2-8C
Embalagem : 1X10MG