16HBE14o- Human Bronchial Epithelial Cell Line

REF : SCC150
Marca : Sigma-Aldrich
Descrição :16HBE14o- Human Bronchial Epithelial Cell Line 16HBE14o- human bronchial epithelial cell line is widely used to model barrier function of the airway epithelium and to study respiratory ion transport as well as the function of CFTR.
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Descrição detalhada : 16HBE14o- is a human bronchial epithelial cell line isolated from a 1-year old male heart-lung patient and immortalized with the origin-of-replication defective SV40 plasmid (pSVori-). The cell line retains characteristic features of normal differentiated bronchial epithelial cells including a cobblestone morphology, cytokeratin expression, the ability to form tight junctions, and directional ion transport (1). When grown with an air/liquid interface, cilia can be detected. In contrast to most other respiratory cell lines, 16HBE14o- expresses high levels of cystic fibrosis transmembrane conductance regulator (CFTR) mRNA and protein (1). Expression of CFTR is correlated to cAMP-dependent Cl- conductance in a variety of cells, including 16HE14o- epithelial cells.
Sinónimos : 16HBE, 16-HBE, 16HBEo-, 16-HBEo, 16-HBE14o
Armazenamento : liquid N2 (-196°C)
Embalagem : 1X1EA