2ʹ,5ʹ-Dideoxyadenosine – CAS 6698-26-6 – Calbiochem

Descrição detalhada : Cell-permeable, non-competitive adenylate cyclase inhibitor (IC50 = 3 µM), that binds to the adenosine P1 binding site. Blocks positive inotropic and chronotropic effects of beta-adrenergic agents., Membrane-permeable adenylate cyclase inhibitor that binds non-competitively to the enzyme via the P-site. Its inhibitory effect varies widely among tissues (IC50 = 3 µM for detergent solubilized rat brain membranes; IC50 = 45 µM for purified bovine brain enzyme). Blocks the forskolin-induced activation of adenylate cyclase activity (IC50 = 540 µM) in cultured bovine aortic endothelial cells. Also blocks the positive ionotropic and chronotropic effects of beta-adrenergic agents.
Sinónimos : 2?,5?-Dideoxyadenosine - CAS 6698-26-6 - Calbiochem; 2?,5?-dd-Ado
Fórmula molecula r: C10H13N5O2
Armazenamento : 2-8C; 2-8C
Embalagem : 1X1MG