3,4-Dichloroisocoumarin – CAS 51050-59-0 – Calbiochem

Descrição detalhada : A potent, irreversible inhibitor of serine proteases. Reacts with serine proteases to release an acylchloride moiety that can acylate another active site residue. Inhibits granzyme B and blocks apoptotic internucleosomal DNA cleavage in thymocytes without the involvement of endonucleases. Does not affect thiol proteases and metalloproteases. Does not exhibit any activity towards beta-lactamases., A potent irreversible inhibitor of serine proteases. Blocks apoptotic internucleosomal DNA cleavage in thymocytes without the involvement of endonucleases. Reacts with serine proteases to release an acylchloride moiety that can acylate another active site residue. Does not affect thiol proteases and metalloproteases. Also has no activity towards beta-lactamases. Effective at concentrations ranging from 5-100 µM., Effective concentration: 5-100 µM; t1/2 = 20 min at pH 7.5.
Sinónimos : 3,4-Dichloroisocoumarin - CAS 51050-59-0 - Calbiochem
Fórmula molecula r: C9H4Cl2O2
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X10MG