[6]-Gingerol, Zingiber officinale – CAS 23513-14-6 – Calbiochem

Descrição detalhada : Phytochemical compound isolated from the extract of rhizome of ginger. Along with other related compounds found in ginger extracts inhibits prostaglandin and leukotriene biosynthesis through the suppression of 5-lipoxygenase and prostaglandin synthetase. Also exhibits anti-tumor and apoptosis-inducing effects. Blocks EGF-induced cell transformation by inhibiting the activation of Activator protein-1 (AP-1). Shown to inhibit the EGF-induced, sequence-specific DNA-binding of AP-1. Does not effect EGF-induced phosphorylation of ERK or p38 kinases. Also increases the Ca2+-ATPase activity of the sarcoplasmic reticulum (EC50 = 4 µM)., An antitumor, apoptosis-inducing compound of the ginger family that blocks EGF-induced cell transformation by inhibiting the activation of Activator Protein-1 (AP-1). Also increases the Ca2+-ATPase activity in cardiac sarcoplasmic reticulum (EC50 = 4 µM) and increases Ca2+ uptake.
Sinónimos : [6]-Gingerol, Zingiber officinale - CAS 23513-14-6 - Calbiochem; 1-(4?-Hydroxy-3?-methoxyphenyl)-5-hydroxy-3-decanone
Fórmula molecula r: C17H26O4
Armazenamento : -20C
Embalagem : 1X5MG