6-Hydroxydopamine hydrochloride

Descrição detalhada : 6-Hydroxydopamine hydrochloride (6-OHDA) is a neurotoxin, commonly used to induce Parkinson?s disease (PD). 6-OHDA causes death of dopaminergic neurons in substantia nigra pars compacta progressively mimicking PD. 6-OHDA is highly oxidizable and cannot cross blood brain barrier. 6-OHDA exerts cytotoxicity by generating reactive oxygen species, initiating cellular stress and cell death. 6-OHDA leads to neuronal cell death in many in vitro models like primary neuronal culture, human neuroblastoma cell line and rat adrenal pheochromocytoma cell line, PC12.
Sinónimos : 2,4,5-Trihydroxyphenethylamine hydrochloride; 2,5-Dihydroxytyramine hydrochloride; 2-(2,4,5-Trihydroxyphenyl)ethylamine hydrochloride; 6-OHDA
Fórmula molecula r: (HO)3C6H2CH2CH2NH2 · HCl
Armazenamento : room temp
Embalagem : 1X1G