Adapalene – CAS 106685-40-9 – Calbiochem

Descrição detalhada : A cell-permeable naphthoic acid compound that exhibits selective affinity and agonistic potency toward RARbeta and RARgamma over RARalpha (Kd = 34, 130, and 1100 nM, respectively; AC50 = 2.3, 9.3, and 22 nM, respectively, in COS-7-based reporter assays) without appreciable affinity toward cytosolic retinoic acid binding proteins CRABP I/II (Kd >>1 µM) or detectable activity toward RXRalpha (AC50 >1 µM). The biological activity and pharmaceutical efficacy of ADA are generally shown to be superior to those of ATRA/Tretinoin (Cat. No. 554720) both in vitro and in vivo., A cell-permeable naphthoic acid compound that exhibits selective affinity and agonistic potency toward RARbeta and RARgamma over RARalpha (Kd = 34, 130, and 1100 nM, respectively; AC50 = 2.3, 9.3, and 22 nM, respectively, in COS-7-based reporter assays) without appreciable affinity toward cytosolic retinoic acid binding proteins CRABP I/II (Kd >>1 M) or detectable activity toward RXRalpha (AC50 >1 M). The biological activity and pharmaceutical efficacy of ADA are generally shown to be superior to those of ATRA/Tretinoin both in vitro and in vivo.
Sinónimos : Adapalene - CAS 106685-40-9 - Calbiochem; CD271, RAR Agonist V, ADA, Differin, 6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid, CD 271; Differin, 6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid, CD 271, CD271, RAR Agonist V, ADA
Fórmula molecula r: C28H28O3
Armazenamento : 2-8C; 2-8C
Embalagem : 1X25MG