Alsterpaullone – CAS 237430-03-4 – Calbiochem

Descrição detalhada : A cell-permeable, potent, reversible, and ATP competitive inhibitor of cdk1/cyclin B (IC50 = 35 nM) and GSK-3β (IC50 = 4 nM). One of the most active paullones that acts by competing with ATP for binding to GSK-3β and inhibits the phosphorylation of tau. Also inhibits the activity of Cdk5/p25-dependent phosphorylation of DARPP-32 (a 32 kDa dopamine and adenosine 3′,5′-monophosphate-regulated phosphoprotein). Displays remarkable antitumor activity in vitro. Inhibits growth of the colon cancer cell line HCT-116, with an IC50 in the nanomolar range., A cell-permeable, potent, reversible, and ATP competitive inhibitor of GSK-3beta (IC50 = 4 nM) and Cdk1/cyclin B (IC50 = 35 nM). Displays remarkable in vitro antitumor activity. Inhibits Tau phosphorylation at sites that are typically phosphorylated by GSK-3beta in Alzheimer's disease. Also inhibits Cdk5/p25-dependent phosphorylation of DARPP-32.
Sinónimos : Alsterpaullone - CAS 237430-03-4 - Calbiochem; 9-Nitro-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one, 9-Nitropaullone, NSC 705701
Fórmula molecula r: C16H11N3O3
Armazenamento : -20C
Embalagem : 1X1MG