AMPK Inhibitor, Compound C – CAS 866405-64-3 – Calbiochem

Descrição detalhada : A cell-permeable pyrrazolopyrimidine compound that inhibits against KDR/VEGFR2, ALK2/BMPR-I, AMPK kinase activity (IC50 = 25.1, 148, and 234.6 nM, respectively), while exhibiting much reduced or little effect toward ALK5/TGFbetaR-I, ZAPK, Syk, PKCtheta, PKA, or JAK3. Shown to block both BMP pathway-dependent dorsoventral development (EC100 = 2.5 µM) and VEGF signaling-dependent intersomitic vessel formation (EC50 = 5 µM) in zebrafish embryo in vivo. Commonly used in combination with AMPK activators AICAR (Cat. No. 123040) and/or Metformin (Cat. No. 317240) for studying AMPK-dependent cellular events in vitro and physiological responses in animals in vivo. Also available as a 10 mM solution in DMSO (Cat. No. 171261).
Sinónimos : AMPK Inhibitor, Compound C - CAS 866405-64-3 - Calbiochem; 6-[4-(2-Piperidin-1-yl-ethoxy)-phenyl)]-3-pyridin-4-yl-pyrrazolo[1,5-a]-pyrimidine, Dorsomorphin, BMP Inhibitor I, AMPK Inhibitor I
Fórmula molecula r: C24H25N5O
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X5MG