Anti-AdipoR2 Antibody, clone 4D3.2

Descrição detalhada : Adiponectin receptor protein 2 (UniProt Q86V24; also known as Progestin and adipoQ receptor family member II) is encoded by the ADIPOR2 (also known as PAQR2) gene (Gene ID 79602) in human. Adiponectin receptor protein 1 & 2 (AdipoR1 & AdipoR2) are receptors for adiponectin, a well knonwn anti-inflammatory adipokine highly abundant in serum. Both AdipoR1 and AdipoR2 are reported to be ubiquitously expressed with the highest expression in skeletal muscle and liver, respectively. Circulating adiponectin levels are reduced in obesity and type II diabetes, whereas weight loss elevates serum adiponectin. Adiponectin deficiency in mice is reported to exacerbate metabolic dysfunction by diet-induced obesity in some studies, while adiponectin overexpression alleviates metabolic dysfunction independent of weight loss in both genetic and diet-induced animal models of obesity. Adipor1-knockout (KO) results in increased adiposity and decreased glucose clearance in mice, whereas Adipor2-KO mice are lean and displayed improved glucose clearance. In addition to its metabolic role, adiponectin deficiency is associated with various clinical cardiovascular disorders including myocardial infarction, peripheral artery disease, and endothelial dysfunction. In a study of murine hind limb ischemia model, blood flow recovery after chronic hind limb ischemic surgery is similar among wild-type and AdipoR1-KO mice, while revascularization in AdipoR2-KO mice is severely attenuated. Human AdipoR2 is a 7-transmembrane (a.a. 148-168, 182-202, 214-234, 246-266, 274-294, 310-330, 349-369) protein with the opposite topology of G protein-coupled receptors (GPCRs), having its N-terminal end at the cytoplasmic side (a.a. 1-147) and C-terminal end at the extracellular side (a.a. 370-386). Unlike GPCRs also, adipoR1 & AdipoR2 transmembrane helices are not kinked or tilted relative to the plane of the membrane.
Sinónimos : Adiponectin receptor protein 2, AdipoR2, Progestin and adipoQ receptor family member II
Armazenamento : +2°C to +8°C
Embalagem : 1X1EA