Anti-AMPylated Tyrosine Antibody

Descrição detalhada : AMPylation is a reversible post-translational modification in which adenosine monophosphate (AMP) derived from ATP is added to threonine and tyrosine (and possibly serine) residues on target proteins. This modification is created by proteins containing Fic (filamentation induced by cyclic adenosine monophosphate) domains, which are present in both prokaryotic and eukaryotic cells. In mammals, the HYPE protein is the most widely known Fic-containing protein and the precise function of its AMPylated targets is not yet clear. However, bacterial cells possess numerous Fic-domain proteins that modify and disable protein targets in host cells, thereby suppressing signaling pathways and increasing the robustness of pathogenic infections. The Vibrio parahaemolyticus VopS protein, for instance, disrupts the function of Rho guanine triphosphatases, and eventually disrupts the actin cytoskeleton.
Sinónimos : AMPylated Tyrosine
Armazenamento : -20°C
Embalagem : 1X1EA