Anti-ARTS antibody, Mouse monoclonal

Descrição detalhada : 1,2 ARTS was later shown to be a key apoptotic protein mediating apoptosis initiated by other inducers. , Anti-ARTS antibody, Mouse monoclonal (mouse IgG2b isotype) is derived from the ARTS51 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from a BALB/c mouse immunized with a synthetic peptide corresponding to C-terminus of human ARTS protein, conjugated to KLH. ARTS (Apoptosis Related protein in the TGF-? signaling pathway), is a novel protein involved in the apoptotic pathways of transforming growth factor-? (TGF-?). The protein is derived from the human septin H5/PNUTL2/CDCrel-2a/2b gene. ARTS consists a phosphate-binding site (P-loop) death domain, which is conserved in all septins and in many different classes of ATP/GTPases. It is localized to mitochondria and translocates to the nucleus, coincident with apoptotic signals induced by TGF-?., Apoptosis-related protein in TGF-? signaling pathway (ARTS) is a novel mitochondrial protein that mediates apoptosis induced by a variety of pro-apoptotic stimuli. Originally found to be essential for apoptosis induced by transforming growth factor-? (TGF-?) ARTS was later shown to be a key apoptotic protein mediating apoptosis initiated by other inducers. Mouse monoclonal anti-ARTS antibody recognizes an epitope within amino acids 247-266 of human ARTS molecule.
Sinónimos : Anti-Apoptosis-Related Protein in the TGF-beta Signaling Pathway; Monoclonal Anti-ARTS antibody produced in mouse
Armazenamento : -20C
Embalagem : 1X.1ML