Anti-AUF1 Antibody

Descrição detalhada : A+U Rich RNA Binding Factor (AUF1) is comprised of four isoforms of 37, 40, 42, and 45 kDa. Although the role of each isoform has yet to be fully characterized, a direct correlation has been observed between each AUF1 isoform's binding affinity and its RNA destabilizing activity toward different AREs (A + U rich element in the 3' untranslated region), with the isoforms p37 and p42 being the most effective. AUF1 is a bcl2 mRNA binding protein and potentially all its isoforms are able to form complexes with the bcl2 ARE. ARE mediated bcl2 mRNA downregulation during apoptosis involves AUF1 and suggest different roles for its four isoforms.
Sinónimos : Anti-AUF1; Anti-AUF1A; Anti-HNRPD; Anti-P37; Anti-hnRNPD0
Armazenamento : -20°C
Embalagem : 1X1EA