Anti-beta-Amyloid (13-28) antibody, Mouse monoclonal

Descrição detalhada : Amyloids are insoluble protein aggregates consisting of misfolded proteins and peptides. Amyloid deposition are associated with multiple neurodegenerative disorders. , The ?-amyloid precursor protein (APP) is cleaved sequentially by the proteolytic enzymes ?-secretase (BACE1) and ?-secretase to produce ?-amyloid (A?) peptides with the A?1-42 and the A?1-40 forms being the most prevalent. Secreted A? peptides are degraded either via a re-uptake mechanism followed by endosomal degradation, or by an extracellular insulin degrading enzyme. Extracellular accumulation of A? leads to the formation of aggregates, fibrils and eventually amyloid deposits called neuritic plaques, which is the hallmark of Alzheimer?s disease (AD).Monoclonal Anti ?-Amyloid [13-28] recognizes the ?-Amyloid peptide. The antibody epitope resides within amino acids 20-23.
Sinónimos : Anti-Abeta
Armazenamento : -20C
Embalagem : 1X25UL