Anti-beta-Amyloid antibody, Mouse monoclonal

Descrição detalhada : The antibody reacts specifically with beta-amyloid protein. The epitope recognized by the antibody resides within amino acids 1-12 of the beta-amyloid protein. It specifically stains amyloid plaques within the cortex and amyloid deposits in blood vessels using formic acid-treated, formalin-fixed, paraffin-embedded, and Methacarn-fixed sections of human Alzheimer's disease (AD) brain tissue., ?-amyloid gene is located on human chromosome 21q21., The ?-amyloid precursor protein (APP) is cleaved sequentially by the proteolytic enzymes ?-and ?-secretase to produce ?-amyloid (A?) peptides with the A?1-42 and the A?1-40 forms being the most prevalent. Secreted A? peptides are degraded either via a re-uptake mechanism followed by endosomal degradation, or by an extracellular insulin degrading enzyme. Extracellular accumulation of A? leads to the formation of aggregates, fibrils and eventually amyloid deposits called neuritic plaques, which is the hallmark of Alzheimer?s disease (AD).
Sinónimos : Anti-A-BETA; Anti-Amyloid beta Precursor Protein; Clone BAM91
Armazenamento : -20C
Embalagem : 1X25UL