Anti-beta-Amyloid antibody, Mouse monoclonal

Descrição detalhada : Amyloid ?-peptide (A?), a 38 to 43 amino acid peptide is obtained from the ?-amyloid precursor protein (APP). ?-amyloid gene is located on human chromosome 21q21. APP is a type I transmembrane protein. It is produced in the endoplasmic reticulum (ER) and then migrated with the help of Golgi apparatus to the trans-Golgi-network (TGN)., The antibody recognizes human beta-amyloid peptide, full-length amyloid precursor protein (APP), soluble-APP (sAPPbeta' and sAPPalpha), C99 cleavage form, and Abeta (1-40/42), but not soluble-APP form sAPPbeta., The ?-amyloid precursor protein (APP) is cleaved sequentially by the proteolytic enzymes ?-secretase (BACE1) and ?-secretase to produce ?-amyloid (A?) peptides with the A?1-42 and the A?1-40 forms being the most prevalent. Secreted A? peptides are degraded either via a re-uptake mechanism followed by endosomal degradation, or by an extracellular insulin degrading enzyme. Extracellular accumulation of A? leads to the formation of aggregates, fibrils and eventually amyloid deposits called neuritic plaques, which is the hallmark of Alzheimer?s disease (AD).
Sinónimos : Anti-Abeta
Armazenamento : -20C
Embalagem : 1X100UL