Anti-beta-Tubulin-FITC antibody, Mouse monoclonal

Descrição detalhada : ?-Tubulin belongs to the subfamily of tubulins. It has two ?-sheets enclosed by ?-helices. It also contains an N-terminal domain with the guanine nucleotide-binding region, an intermediate domain with taxol-binding site and a C-terminal domain, which has the binding surface for molecular motor proteins. Human ?-tubulin consists of seven isoforms (?I (class I), ?II (class II), ?III (class III), ?IVa (class IVa), ?IVb (class IVb), ?V (class V), and ?VI (class VI)). TUBB1 (tubulin beta class I) is located on human chromosome 6p21.33.(10), Tubulin is the major building block of microtubules. This intracellular cylindrical filamentous structure is present in almost all eukaryotic cells. Microtubules function as structural and mobile elements in mitosis, intracellular transport, flagellar movement, and in the cytoskeleton. Tubulin is a heterodimer, which consists of ?-tubulin and ?-tubulin; both subunits have a molecular weight of 55 kDa and share considerable homology. The most studied tubulins have been isolated from vertebrate brains. The microtubules can be viewed in immunofluorescent microscopy, which enables the observation of the intracellular organization of proteins that are in the form of a supramolecular structure.
Sinónimos : Monoclonal Anti-beta-Tubulin
Armazenamento : -20C
Embalagem : 1X.2ML