Anti-c-Myc Antibody, clone 9E10

Descrição detalhada : c-Myc (bHLHe39) is a transcription factor that regulates the expression of multiple genes involved in apoptosis, cell differentiation and cell proliferation. Active c-Myc is coupled to the MAX protein via c-Myc's C-terminal helix-loop-helix leucine zipper (bHLHLZ) domain. The c-Myc-MAX heterodimer also interacts with a number of other transcription-related proteins including TRRAP, p107 and Miz-1, and c-Myc-MAX may indirectly regulate histone acetylases involved in chromatin remodeling to increase accessibility of transcriptional complexes to target DNA sequences. The expression of c-Myc is controlled by growth factors. Several studies have reported abnormal expression of c-Myc in various cancers including Burkitt's lymphoma.
Sinónimos : Myc proto-oncogene protein, Class E basic helix-loop-helix protein 39, HLHe39, Proto-oncogene c-Myc, Transcription factor p64
Armazenamento : +2°C to +8°C
Embalagem : 1X1EA