Anti-CAVIN-3/PRKCDBP Antibody

Descrição detalhada : CAVIN-3/PRKCDBP, also known as Cavin-3/SRBC or Serum deprivation response factor-related gene product that binds to C-kinase, and encoded by the gene Prkcdbp/Srbc, is an adapter molecule that binds PKCdelta and is a member of the STICK (substrates that interact with C-kinase) superfamily of PKC-binding proteins. CAVIN-3 binds caveolin and localizes to the caveolae. CAVIN-3 remains associated with caveolin when caveolae bud to form vesicles (cavicles) that travel on microtubules to different regions of the cell. In the absence of CAVIN-3 intracellular cavicle traffic is markedly impaired. CAVIN-3 is also called SRBC for (sdr-related gene product that binds to c-kinase). Caveolae are a major membrane domain common to most cells. One of the defining features of this domain is the protein caveolin, and it is now know that CAVIN-3 is critical to caveolae function. CAVIN-3 is expressed in uterus, ovary, mammary and epithelial cells. Also expressed in brain, lung, heart, spleen, intestine, kidney, skeletal muscle and testis, but it is not found in liver. The protein appears to be up-regulated in serum starved conditions and growth arrest conditions suggesting a survival response.
Sinónimos : Protein kinase C delta-binding protein, Cavin-3, Serum deprivation response factor-related gene product that binds to C-kinase
Armazenamento : -20°C
Embalagem : 1X1EA