Anti-Chromobox protein homolog 5 Antibody

Descrição detalhada : Chromobox protein homolog 5, also known as Antigen p25, Heterochromatin protein 1 homolog alpha (HP1 alpha), and encoded by the gene name CBX5 or HP1A is a component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, Chromobox protein homolog 5 is excluded from chromatin when 'Tyr-41' of histone H3 (H3Y41ph) is phosphorylated. CBX5 is implied to interact with lamin-B receptor (LBR), which can contribute to the association of the heterochromatin with the inner nuclear membrane. Recent studies have shown that CBX5 is involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Heterochromatin is characterized as densely coiled chromatin that generally replicates late during S phase, has a low gene density, and contains large blocks of repetitive DNA that is relatively inaccessible to DNA-modifying reagents. In late S phase, p150 directly associates with heterochromatin associated proteins 1 (HP1alpha, HP1beta and HP1gamma). As cells prepare for mitosis, CAF-1 p150 and some HP1 progressively dissociate from heterochromatin, coinciding with the phosphorylation of histone H3. The HP1 proteins reassociate with chromatin at the end of mitosis, as histone H3 is dephosphorylated.
Sinónimos : Chromobox protein homolog 5, Antigen p25, Heterochromatin protein 1 homolog alpha, HP1 alpha
Armazenamento : +2°C to +8°C
Embalagem : 1X1EA