Anti-Coilin antibody, Mouse monoclonal

Descrição detalhada : Monoclonal Anti-Coilin (mouse IgG1 isotype) is derived from the p? hybridoma produced by the fusion of mouse myeloma cells and splenocytes from mice immunized with coilin. Coilin contains two nuclear localization sequences (NLS) (at amino acid 107-112 and 181-198) and several serine residues that are phosphorylated in vivo. The description of specific intranuclear structures known today as Cajal bodies was first published in 1903 by the neuro-cytologist Ramon-?-Cajal who discovered that neurons contained spherical structures of around 0.5 ?m in diameter that were often associated with nucleoli, nucleolar accessory bodies. It was found that patients with auto-antibodies against coiled bodies recognize a protein of 80 kDa termed p80-coilin. Nuclear antigens shown to colocalize with p80 coilin in Cajal bodies include basal transcription factors, cell cycle factors (cdks), splicing snRNPs and nucleolar factors including snoRNP.
Sinónimos : Anti-CLN80; Anti-p80-coilin
Armazenamento : -20C
Embalagem : 1X200UL