Anti-CRB1 Antibody, clone 1C2.1

Descrição detalhada : Protein crumbs homolog 1 (UniProt P82279) is encoded by the CRB1 (also known as LCA8, RP12) gene (Gene ID 23418) in human. The Crumbs protein was first identified in Drosophila as a key developmental regulator of apical polarity. In mammals, the family is composed of three genes, CRB1, CRB2 and CRB3. CRB1 is synthesized with a signal (a.a. 1-25) sequence that is removed posttranslationally to yield the mature protein with a large extracellular domain (a.a. 26-1347) composed of 19 EGF-like domains (a.a. 30-1333) and three Laminin G-like domains (between EGF-like domains 11&12, 12&13, 14&15), followed by a transmembrane domain (a.a. 1348-1368) and a short cytoplasmic tail (a.a. 1369-1406) that interacts with PALS1/MPP5, PATJ and MUPP1 to form the core CRB complex. The apical CRB complex resides at the subapical region above the adherens junctions between photoreceptors and Mueller glia cells in mouse and human. In adult mouse retinas, CRB1 is expressed only in Mueller glia cells and maintains adherens junctions between photoreceptors and Mueller glia cells, while in human retina, CRB1 protein is expressed at the subapical region in photoreceptors and Mueller glia cells. CRB1 mutations are found in various retinal dystrophies, chronic and disabling disorders of visual function, including Retinitis pigmentosa 12 (RP12) and Leber congenital amaurosis 8 (LCA8).
Sinónimos : Protein crumbs homolog 1
Armazenamento : +2°C to +8°C
Embalagem : 1X1EA