Anti-Desmoglein-1 Antibody, clone 32-2B

Descrição detalhada : Desmoglein-1 (DSG1) is a transmembrane glycoprotein belonging to the family of cadherins. It is one of the main structural components of desmosomal junctions which are abundant in tissues undergoing frequent mechanical stress, such as the heart, epidermis, lymphatic endothelial cells, and meninges. The desmoglein-1 subtype is highly expressed in the epidermis. Like other cadherins, desmoglein-1 contains multiple calcium binding sites and a cell-adhesion recognition site which facilitates intercellular adhesions. Desmoglein-1 is regulated by calcium and PKCalpha signaling, and is also coupled to intermediate filaments of the cytoskeleton. Desmosomes play a critical role in cell and tissue stability, and may contribute to the progression of cancer.
Sinónimos : Desmoglein-1, Desmosomal glycoprotein 1, DG1, DGI, Pemphigus foliaceus antigen
Armazenamento : +2°C to +8°C
Embalagem : 1X1EA