Anti-Fas (CD95/Apo-1) antibody, Mouse monoclonal

Descrição detalhada : Many cells can be activated to undergo apoptosis following the interaction of selected ligands with cell surface receptors. The most well studied receptors are CD95/Fas/Apo-1 (apoptosis inducing protein 1) and tumor necrosis factor receptor 1 (TNFR1). Apoptosis mediated by either of these results in activation of the caspases. However, Fas-mediated death occurs much more rapidly than that triggered by TNFR1. Human Fas/CD95/Apo-1 is a single transmembrane glycoprotein receptor (325 amino acids, 45-48 kDa). , Monoclonal Anti-Human Fas (CD95/Apo-1) (mouse IgG1 isotype) is derived from the DX2 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from C3H mice immunized with murine L cells transfected by a human Fas/CD95 cDNA. CD95/Fas/Apo-1 exhibits strong homologies with the extracellular domain of receptors belonging to the tumor necrosis factor (TNF) receptor family, which includes TNF receptor types 1 and 2 (TNFR1/2), the low affinity nerve growth factor receptor, and lymphocyte receptors such as CD27, CD30, CD40, and OX40. Fas is an integral membrane protein, with strong homology to TNF-alpha and -beta , has been identified as Fas ligand.
Sinónimos : Monoclonal Anti-Fas; Monoclonal Anti-Fas (CD95/Apo-1) antibody produced in mouse; Anti-Apo-1; Anti-CD95
Armazenamento : -20C
Embalagem : 1X.1ML