Anti-gamma-Actin antibody, Mouse monoclonal

Descrição detalhada : Monoclonal Anti-?-Actin (mouse IgG1 isotype) is derived from the hybridoma 2-2.1.14.17 produced by the fusion of mouse myeloma cells (NS1) and splenocytes from BALB/c mice. Actin is one of the most conserved eukaryotic proteins, it is expressed in mammals and birds as at least six isoforms. Actin isoforms show more than 90% overall sequence homology, but only 50-60% homology in their 18 NH2-terminal residues. Actin constitutes for around 15% of the total protein. It exists in globular and filamentous forms., ?-Actin is mainly present in sarcolemma and to a lesser extent in reticular lattice of normal muscles. Increased levels of ?-actin have been linked to dystrophin loss and subsequent cell signaling and gene expression defects.
Sinónimos : Anti-ACTG1
Armazenamento : -20C
Embalagem : 1X200UL