Anti-Histone-lysine N-methyltransferase NSD3 Antibody

Descrição detalhada : Histone-lysine N-methyltransferase NSD3, also known as Nuclear SET domain-containing protein 3, Protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine or Wolf-Hirschhorn syndrome candidate 1-like protein 1, (WHSC1-like protein 1), and encoded by the gene WHSC1L1/NSD3, is a histone methylase that preferentially methylates Lys-4 and Lys-27 of histone H3. Lys-4 methylation is generally a specific tag for transcriptional activation while Lys-27 methylation is a mark for transcriptional repression. NSD3 is highly expressed in many tissues including the brain, heart and skeletal muscle. Overexpression of NSD3 is associated with certain forms of lung cancer as well as certain other cancers. NSD3 also facilitates the expression of many other genes important in cancer progression such as Brd4. Brd4 through its extraterminal domain interacts with NSD3 which regulates transcription by modifying the chromatin microenvironment at Brd4 target genes.
Sinónimos : Histone-lysine N-methyltransferase NSD3, Nuclear SET domain-containing protein 3, Protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1, WHSC1-like protein 1
Armazenamento : +2°C to +8°C
Embalagem : 1X1EA