Anti-IFI-16 antibody, Mouse monoclonal

Descrição detalhada : The gene IFI-16 (interferon, ?-inducible protein 16) encodes a member of the interferon-inducible nuclear proteins family containing one or two copies of a conserved 200 amino acid repeat domain called HIN-200 domain. It has three different isoforms, IFI-16A, -16B, -16C. The IFI-16A isoform is the longest with 785 amino acids. IFI-16B is the most broadly expressed isoform with 729 amino acids and IFI-16C has 56 amino acids lesser. The three isoforms have serine and threonine residues which can be phosphorylated. The N-terminus contains an imperfect leucine zipper domain, where the isoforms homo- and heterodimerize. IFI-16 contains an N-terminal domain called DAPIN/PYRIN/CARD that may be involved in protein-protein interactions. IFI-16 is expressed in some haemopoietic lineages , such as CD34+ progenitor cells, mature lymphocytes and monocytes. The gene is mapped to human chromosome 1q22.
Sinónimos : Anti-Interferon-inducible 16
Armazenamento : -20C
Embalagem : 1X200UL