Anti-Interferon-gamma antibody produced in goat

Descrição detalhada : Interferons (IFNs) are cytokines that are secreted in response to viral or bacterial infections and tumorigenesis. There are two types of IFNs, type I (IFN-? and IFN-?) and type II (IFN-?). IFN-? binds to specific receptor complex consisting of IFN?R1 and IFN?R2. There are many pathways that are mediated by IFN-? binding such as JAK/STAT1, AP-1, NF-?B, STAT3 and STAT5. IFN-? is pleotropic and performs various functions related to immune response, inflammation, differentiation and activation of T cells, cell cycle and apoptosis. The most studied function of IFN-? is priming the antigen presenting cells by upregulating major histocompatibility (MHC) Class I molecules. IFN-? has clinical applications in autoimmune diseases (rheumatoid arthritis), multiple sclerosis, cancer, HIV and fungal infections Anti-Interferon-? recognizes human Interferon-?. It does not bind specifically to mouse, hamster or bovine IFN-?.
Sinónimos : Anti-IFN-gamma
Armazenamento : -20C
Embalagem : 1X1MG