Anti-Interleukin-4 Soluble Receptor antibody produced in goat

Descrição detalhada : Interleukin-4 (IL-4) is a T cell derived chemokine that stimulates the Th2 mediated immune response and proliferation of B cells. The effects of IL-4 are mediated by two types of receptors, type I receptor consisting of IL-4R? and common ? chain and type II receptor composed of IL-4R? and IL-13R?1. The signalling stimulated by IL-4R leads to activation of JAK/STAT6 and IRS-mediated PI3K/Akt pathway. Through these pathways, IL-4 is responsible for endocytic activity of macrophages, chemotaxis of leukocytes in response to inflammation, angiogenesis and regulation of nitric oxide metabolism in macrophages. Anti-tumor effects of IL-4R signaling have been reported in cancers of breast, liver and renal cells Anti-Interleukin-4 soluble receptor specifically recognizes human cell surface IL-4R.
Sinónimos : Anti-IL-4 sR
Armazenamento : -20C
Embalagem : 1X1MG