Anti-Interleukin-7 Receptor alpha/CD127 antibody produced in goat

Descrição detalhada : Interleukin-7 (IL-7) is a stromal-cell derived cytokine that is important in the development of adaptive immunity and maintenance of T cells and B cells. The cognate receptor that binds IL-7 is the IL-7 receptor complex, made up of IL-7 R ? chain and a ? chain. The expression of IL-7 R is restricted to immature B cells, mature T cells and thymocytes. The binding of IL-7 to its receptor triggers a variety of tightly regulated signalling pathways that are critical for cell survival, proliferation, differentiation and uptake of glucose. The signalling pathways that participate in mediating the effects of IL-7 R are JAK/STAT and PI3K. Additionally the effect of IL-7 on cell cycle is due to the modulation of proteins p27kip1 and Cdc25A. Reports implicate IL-7 R in glucose metabolism and cell size as it modulates the effects of GLUT4 Anti-interleukin-7 receptor ?/CD127 recognizes human interleukin-7.
Sinónimos : Anti-CD127; Anti-CDW127; Anti-IL7R; Anti-ILRA
Armazenamento : -20C
Embalagem : 1X100UG