Anti-IRS1 Antibody, clone 58-10C-31, rabbit monoclonal

Descrição detalhada : IRS1 (Insulin Receptor Substrate 1) transmits insulin signals via metabolic and mitogenic pathways. It is heavily phosphorylated on both serine and tyrosine residues. These phosphorylated tyrosines enable IRS to act as a docking protein that binds SH2 domains of such proteins as PI3 Kinase (phosphatidylinositol 3-kinase) and GRB2, resulting in activation. Over expression and phosphorylation of serine is associated with insulin resistance and breast cancer.
Sinónimos : insulin receptor substrate 1
Armazenamento : -20°C
Embalagem : 1X1EA