Anti-Kindlin-1 Antibody, clone 4A5.14

Descrição detalhada : The Kindlin family is a group of focal adhesion proteins that have recently become a point of interest because of their ability to bind and activate integrins. Abnormalities in this ability have linked Kindlin to several diseases, both inherited and acquired, such as Kindler syndrome, cancer, and leukocyte adhesion deficiency. Specifically associated with Kindler syndrome, is the isoform Kindlin-1 which plays a key role in adhering the actin cytoskeleton to the extracellular matrix of basal keratinocytes. Kindlin-1 may also be involved in tumor growth by modulating TGF-beta 1 signaling (Shi, 2007). It is most widely expressed in the brain, kidney, colon, placenta, skeletal muscle, adrenal gland, and prostate.
Sinónimos : Kindlin syndrome protein, UNC-112 related protein 1, Unc-112-related protein 1, chromosome 20 open reading frame 42, kindlin 1
Armazenamento : +2°C to +8°C
Embalagem : 1X1EA