Anti-Kindlin-3 Antibody, clone 181A

Descrição detalhada : Kindlin-3 is an intracellular protein encoded by the FERMT3 gene and which binds directly to the beta chain cytoplasmic tail of integrin in hematopoietic cells. This protein belongs to a family of adhesion plaque proteins, of which there are three members, which act to activate integrins. Kindlin-3 differs from Kindlins-1 and -2 in that its expression is restricted to hematopoietic systems and is especially high in spleen and megakaryocytes. It is a necessary component for integrin activation and for platelet aggregation. Mutations in FERMT3 and consequently to the encoding of Kindlin-3 protein are causal to LAD-I variant syndrome, an uncommon genetic disorder in which integrin adhesive functions on platelets and leukocytes are disrupted.
Sinónimos : Fermitin family homolog 3, Kindlin-3, MIG2-like protein, Unc-112-related protein 2
Armazenamento : +2°C to +8°C
Embalagem : 1X1EA