Anti-Ly108/Slamf6 Antibody, clone 3E11

Descrição detalhada : SLAM family member 6 (UniProt Q9ET39; also known as CD352, NK-T-B-antigen, NTB-A, Lymphocyte antigen 108) is encoded by the Slamf6 (also known as Ly108) gene (Gene ID 30925) in murine species. Ly108/Slamf6 belongs to the 7-member (SLAM/CD150, CD48/SLAMF2, Ly-9/CD229, 2B4/CD244, CD84/SLAMF5, Ly108/NTB-A/CD352, CRACC) signaling lymphocytic activation molecule family (SLAMF) of receptors broadly expressed in hematopoietic cells. 2B4 and CD48 interact with eath other, while rest of the family members act as self-ligands, where two identical molecules on the surface of two different cells can interact as receptor and ligand to each other. SLAMF members carry one or more copies of immunoreceptor tyrosine-based switch motif or ITSM (TxYxxV/I) in their cytoplasmic tails. Upon phosphorylation on the tyrosine residue, ITSM mediates the recruitment of SH2 domain-containing signaling molecules such as SLAM-associated protein (SAP), including SAP in T-, NK, and NK T-cells, EAT-2A and EAT-2B (murine) in NK cells and APCs. Ly108/Slamf6 is synthesized with a signal peptide sequence (mouse a.a. 1-30), the removal of which yields the mature Ly108 with an extracellular region (a.a. 31-239) that contains a V-type and a C2-type Ig-like domain (a.a. 36-130 and 147-210), followed by a single transmembrane domain (a.a. 240-262) and a cytoplasmic tail (a.a. 263-351). Ly108/Slamf6 cytoplasmic domain contains two copies of ITSM (mouse a.a. 293-TVYAQV-298 and 317-TIYSIV-322). Alternative splicings produce three Ly108 isoforms, Ly108-1 (Ly108s; UniProt Q9ET39-2), Ly108-2 (Ly108l; UniProt Q9ET39-1) and Ly108-3 (Not reported by UniProt), that differ in their cytoplasmic C-terminal end sequence, but are identical in the rest of their sequence.
Sinónimos : SLAM family member 6, CD352, NK-T-B-antigen, NTB-A, Lymphocyte antigen 108
Armazenamento : -20°C