Anti-MACC1 Antibody

Descrição detalhada : Metastasis-associated in colon cancer protein 1, also known as SH3 domain-containing protein 7a5, and encoded by the gene name MACC1, is a key regulator of the hepatocyte growth factor (HGF)-HGF receptor (MET) pathway. This pathway is involved in cellular growth, epithelialmesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 was found significantly upregulated in malignant tissues (colon cancer of all stages as well as liver and lung metastases) compared to normal tissues or adenomas. MACC1 represents an early and crucial prognostic indicator for colon cancer metastasis that is independent of age, sex, tumor infiltration, nodal status, and lymph vessel invasion. Besides its involvement in signal transduction with the MET receptor, MACC1 also links MET signaling and apoptosis. MACC1 may also be an important therapeutic target for colorectal cancer treatment.
Sinónimos : Metastasis-associated in colon cancer protein 1, SH3 domain-containing protein 7a5, MACC1
Armazenamento : +2°C to +8°C
Embalagem : 1X1EA