Anti-Maf-B Antibody

Descrição detalhada : Transcription factor MafB (Maf-B) belongs to the bZIP family as a part of the MAF subfamily and contains a characteristic bZIP domain. Maf-B can function as either a transcriptional activator or repressor. It regulates erythroid differentiation through its interaction with and negative regulation of EST-1 activity. Maf-B is a critical factor in the differentiation of islet beta cells, alpha and beta cells, macrophage, monocytic, and podocyte cells. It is involved in macrophage expression and maturation of F4/80, and regulates renal development and survival of renal tubules. Interaction with SUMO regulates the transcriptional activity of Maf-B along with its function in determining macrophage fate. Studies have shown that, relative to cell context, Maf-B can act as either a tumor or an oncogene suppressor.
Sinónimos : v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian), MAFB/Kreisler basic region/leucine zipper transcription factor, transcription factor MafB, Kreisler (mouse) maf-related leucine zipper homolog, Kreisler maf-related leucine zipper homolog
Armazenamento : -20°C
Embalagem : 1X1EA