Anti-Meis1

Descrição detalhada : Homeobox protein Meis1 (UniProt: Q60954-1; P97367-2 and P97367-3; also known as Myeloid ecotropic viral integration site 1 (Meis1) and Meis1-related protein 1) is encoded by the Meis1 gene (Gene ID: 17268). Meis proteins act as transcription factors that are orthologous to the Drosophila homothorax (Hth) protein. Meis protein contain a TALE (three-amino-acid loop extension) sub-class of the homeodomain that binds to DNA. Meis protein directly bind to Pbx proteins and the Meis/Pbx protein complex binds to DNA through respective Meis- and Pbx-consensus binding sites to regulate transcription. The Meis/Pbx complex plays important roles during development of multiple organs. In humans and mice, three homologues Meis1, Meis2 and Meis3 have been identified. Meis1 is expressed at high levels in the lung and at lower levels in the heart and brain. On the other hand, Meis 2 displays spatially restricted expression patterns in the developing nervous system, limbs, face, and in various viscera. In adult, it is mainly expressed in the brain and female genital tract, with a different distribution of the alternative splice forms in these organs. Pancreatic beta cells express both Meis1 and 2. Both Meis1 and 2 are expressed at high levels in all stages of embryonic development of mice (day 7 to 17). Deficiency of Meis1 or Meis 2 can lead to embryonic lethality. (Ref.: Machon, O et al. (2015). BMC Dev. Biol. 515:40).
Sinónimos : Homebox protein Meis1
Armazenamento : -20°C
Embalagem : 1X25UG