Anti-Met (extracellular) Antibody, clone 4F8.2

Descrição detalhada : The proto-oncogene Met (c-Met, HGF/SF Receptor, HGFR) is a receptor tyrosine kinase that is activated upon Hepatocyte Growth Factor (HGF) binding. This stimulates the autophosphorylation on Tyr1234/Tyr1235 which leads to pleiotropic downstream signaling events in epithelial cells that stimulate multiple cellular processes including cell proliferation, growth, differentiation, cell migration/ invasion, and tumorigenesis. These effects are mediated by SH2 domain-containing proteins that bind to the C-terminal tail of c-Met. Chronic stimulation of Met on cancer cells is thought to play a role in metastasis and dysregulation of c-Met activity is directly associated with oncogenesis, making it an important cancer target.
Sinónimos : HGF receptor, HGF/SF receptor, Met proto-oncogene tyrosine kinase, SF receptor, Scatter factor receptor, met proto-oncogene, met proto-oncogene (hepatocyte growth factor receptor), oncogene MET
Armazenamento : +2°C to +8°C
Embalagem : 1X1EA