Anti-monoubiquityl Histone H2B (Lys119) Antibody, clone 7B4

Descrição detalhada : H2BUb1, also known as Histone H2B.1 A, or Histone H2B.a (H2B/a), or Histone H2B.g (H2B/g), or Histone H2B.h (H2B/h), or Histone H2B.k (H2B/k) or Histone H2B.i (H2B/I;H2B/I), and encoded by the gene HIST1H2BC or HIST1H2BE, HIST1H2BF, HIST1H2BG, HIST1H2BI/H2BFL, H2BFH, H2BFG, H2BFA, H2BFK, is a core component of the nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. H2BUb1 also has broad antibacterial activity and may contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. H2BUb1 is localized to the nucleus and chromosomes in healthy cells.
Sinónimos : H2BUb1, Histone H2B type 1-C/E/F/G/I, Histone H2B.1 A, Histone H2B.a, H2B/a, Histone H2B.g, H2B/g, Histone H2B.h, H2B/h, Histone H2B.k, H2B/k, Histone H2B.l, H2B/l, H2BUbK119, H2BK119Ub
Armazenamento : +2°C to +8°C
Embalagem : 1X1EA