Anti-Myelin Basic Protein Antibody, a.a. 129-138, clone 1

Descrição detalhada : The classic group of MBP isoforms (isoforms 4-14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoforms 1-3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined to optional posttranslational modifications give a wide spectrum of isomers, each of them having maybe a specialized function. MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system. Isoform 1 Golli-MBP1, HOG7, 33 kDa Isoform 2 Golli-MBP2, HOG5, 21.5 kDa Isoform 3 MBP1, 21.5 kDa Isoform 4 MBP2, 20.2 kDa Isoform 5 MBP3, 18.5 kDa Isoform 6 MBP4, 17.2 kDa (SP_P02686)
Sinónimos : Myelin A1 protein, Myelin membrane encephalitogenic protein, myelin basic protein
Armazenamento : -20°C
Embalagem : 1X1EA