Anti-N-Myc Antibody, clone NCM II 100

Descrição detalhada : The v-myc oncogene, initially identified in the MC29 avian retrovirus, causes myelocytomas, carcinomas, sarcomas and lymphomas, and belongs to a family of oncogenes conserved throughout evolution. In humans the family consists of five genes: c-myc, N-myc, R-myc, L-myc and B-myc. Amplification of the N-myc gene has been found in human neuroblastomas and cell lines. The extent of N-myc amplification correlates well with the stage of neuroblastoma disease. Immunological studies have shown that the human N-myc gene gives rise to at least two nuclear phosphoproteins that exhibit relatively short (30 min) half lives in vivo and exhibit DNA binding properties in vitro.
Sinónimos : N-myc proto-oncogene protein, Class E basic helix-loop-helix protein 37, bHLHe37
Armazenamento : +2°C to +8°C
Embalagem : 1X1EA