Anti-NRF-1 Antibody

Descrição detalhada : Nuclear respiratory factor (UniProt Q9WU00; also known as Alpha-pal, Alpha palindromic-binding protein, NRF-1) is encoded by the Nrf1 gene (also known as C87038, D6Ertd415e) in murine species (Gene ID 18181). NRF-1 is a redox-responsive transcription factor that plays an anti-oxidant, pro-survival role in mitochondrial biogenesis process. NRF-1 is upregulated and activated/phosphorylated by Akt in response to oxidant exposure or increased cellular reactive oxygen species (ROS). This results in NRF-1 nuclear translocation, where it binds to DNA as a homodimer and mediates the transcription of mitochondrial transcription factor A (mtTFA) that is needed for mitochondrial DNA transcription.
Sinónimos : Nuclear respiratory factor 1, NRF-1, Alpha palindromic-binding protein, Alpha-pal, NRF-1
Armazenamento : +2°C to +8°C
Embalagem : 1X1EA