Anti-Osterix (SP7) Antibody, clone 6B12.1

Descrição detalhada : OSTERIX, or SP7, is a zinc finger-containing, osteoblast-specific transcription factor that is distinctly expressed in all developing bones, and is a key requirement for the differentiation of pre-osteoblasts into fully functional osteoblasts. While research on the actual functional mechanisms of OSTERIX is still on-going, current findings indicate that OSTERIX expression is induced by BMP-2 and Dlx5, and operates downstream of RUNX2, supporting its role in mesenchymal stem cell differentiation. Further studies also indicate that the OSTERIX transcription factor may also play a role in negatively regulating the Wnt/beta-catenin signaling pathways and the proliferation of osteroblast cell types during embryonic osteogenesis.
Sinónimos : Transcription factor Sp7, Zinc finger protein osterix
Armazenamento : +2°C to +8°C
Embalagem : 1X1EA