Anti-PAX7 Antibody, clone 2F12H4

Descrição detalhada : Paired box protein Pax-7 (PAX7) belongs to the Pax family of transcription factors, a highly conserved group of proteins with crucial roles in tissue homeostasis and organogenesis. PAX7 is involved in the specification, survival, maintenance, and self-renewal of skeletal muscle progenitors and myogenic progenitors. It is primarily expressed in newly activated and quiescent satellite cells. Studies have shown that on activation, quiescent satellite cells co-express MyoD with PAX7 prior to proliferation, after which one or the other transcription factor is downregulated. Downregulation of MyoD instead of PAX7 leads to withdrawal from the cell cycle and myogenic differentiation, causing the cell to return to seemingly quiescent state. Chromosomal aberrations relating to PAX7 have been linked to rhabdomysarcoma 2 (RMS2).
Sinónimos : paired box 7, PAX7 transcriptional factor, paired box gene 7, paired box homeotic gene 7, paired box protein Pax-7, paired domain gene 7
Armazenamento : +2°C to +8°C
Embalagem : 1X1EA