Anti-phospho-Androgen Receptor (Ser81) Antibody

Descrição detalhada : The X-linked androgen receptor (Dihydrotestosterone receptor; Nuclear receptor subfamily 3 group C member 4) is a member of the family of NR3 ligand-dependent transcription factors characterized by a ligand binding domain at the C-terminus, a central DNA-binding domain, and N-terminal transcription- activation domains. Androgen receptors are activated by steroid hormones such as testosterone and dihydrotestosterone. Activated androgen receptors translocate from the cytoplasm to the nucleus where they form homodimers that bind DNA. The androgen receptor associates with a number of adaptor-like proteins and functions as a complex that may induce or repress transcription depending on whether its associated proteins are co-activators or co-repressors that affect transcription possibly by modifying chromatin; co-activators are involved in histone acetylation and transcriptional activation whereas co-repressors are involved in histone deactylation and transcriptional repression. The androgen receptor is important for determining sex and male characteristics. Defective androgen receptors may play a role in Reifenstein syndrome, Kennedy disease, as well as prostate cancer.
Sinónimos : Anti-AIS; Anti-AR8; Anti-DHTR; Anti-HUMARA; Anti-HYSP1; Anti-KD; Anti-NR3C4; Anti-SBMA; Anti-SMAX1; Anti-TFM
Armazenamento : +2°C to +8°C
Embalagem : 1X1EA